Nowadays, calcium sulfoaluminate cement (CSA) is garnering a large amount of attention worldwide and is being promoted as a sustainable alternative to Portland cement for specific applications. This study aimed to control the heat release of CSA cement paste by choosing the appropriate composition. For this purpose, different calcium sulfoaluminate clinkers with up to 75 wt. % of ye’elimite were synthetized. Then, a reactivity study on the synthesized clinkers was conducted while varying the amount of gypsum added. The heat of hydration was measured by isothermal calorimetry. The influence of the ye’elimite content on the heat release and on the compressive strength was investigated. According to the findings, the amount of ye’elimite in the cement has a direct relationship with the heat release. The heat release as well as the mechanical performance increase with the increase in the ye’elimite content in the CSA cement. An equation allowing the prediction of the total heat release after 24 h is provided. Such data can be of particular interest to consultants aiming at the reduction of thermal cracking in massive concrete.